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Marcel V, Palmero EI, Falagan-Lotsch P et al (2009) TP53 PIN3 and MDM2 SNP309 poly-morphisms as genetic modi?ers in the Li-Fraumeni syndrome: impact on age at ? rst diagnosis.J Med Genet 46:766–772. Glucose is closely monitored every 15–30 minutes to prevent hypo-glycemia

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Essentially, the clear zoneis a compartment at the site of the ruffled border whereresorption and degradation of the matrix occurs.

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